Which methodology is designed to eliminate defects and variability from a process, aiming for less than 3.4 defects per million opportunities?

The methodology that is specifically designed to eliminate defects and variability from a process, aiming for less than 3.4 defects per million opportunities, is Six Sigma. This disciplined, data-driven approach focuses on improving quality by identifying and removing the causes of defects and minimizing variability in manufacturing and business processes. Six Sigma employs a defined strategy known as DMAIC (Define, Measure, Analyze, Improve, Control), which guides teams through a systematic process for quality improvement.

Other methodologies mentioned, such as Lean Manufacturing, Kaizen, and Total Quality Management, focus on efficiency, continuous improvement, and overall quality but do not specifically target achieving a quantified defect rate of less than 3.4 defects per million opportunities. Lean Manufacturing emphasizes waste reduction and efficiency, while Kaizen focuses on continuous improvement through incremental changes. Total Quality Management encompasses overall quality improvements over an organization but does not have the specific defect rate goal that Six Sigma targets. Therefore, Six Sigma is the methodology that best fits the described goal of minimizing defects.